Retatrutide
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Retatrutide

Retatrutide

Product Description

Retatrutide (development code LY‑3437943) is the world's first triple GLP‑1/GIP/glucagon receptor agonist developed by Eli Lilly to enter Phase III clinical trials. It is mainly administered via subcutaneous injection once a week, primarily for the treatment of obesity and type 2 diabetes, and has not yet been approved for marketing.
I. Core Mechanism: Synergy of Triple Pathways
As a single molecule, it simultaneously activates three key metabolic receptors to achieve triple effects of "glycemic control + weight loss + fat burning":
GLP‑1 receptor: Delays gastric emptying, enhances central satiety, stimulates insulin secretion in a glucose-dependent manner, inhibits glucagon, thereby lowering blood glucose and reducing food intake.
GIP receptor: Synergistically improves insulin sensitivity, enhances glucose metabolism, and optimizes fat storage and utilization.
Glucagon (GCGR) receptor: Increases energy expenditure (thermogenesis), promotes lipolysis, and improves hepatic lipid metabolism — this is the key feature that distinguishes it from dual-target agonists such as tirzepatide.

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