Adipotide -Yuan peptide

Adipotide

Product Description

Adipotide (also known as FTPP, Prohibitin‑TP01) is a synthetic peptide targeting apoptosis in adipose blood vessels. Its core function is to selectively cut off the blood supply to white adipose tissue and induce adipocyte apoptosis. At present, it is only used for scientific research purposes and has not been approved for clinical or human use.

I. Basic Information

Full name: Fat‑Targeted Proapoptotic Peptide

Aliases: Prohibitin‑TP01, weight‑loss peptide / adipose peptide

R&D background: Developed by the MD Anderson Cancer Center in the United States in 2004, initially extending the tumor blood vessel targeting strategy to obesity research

Molecular structure: Chimeric peptide, composed of two parts linked by glycine (GG)

Targeting region: CKGGRAKDC (recognizes the Prohibitin receptor on adipose vascular endothelium)

Pro‑apoptotic region: D(KLAKLAK)₂ (triggers programmed death of vascular endothelial cells)

Molecular formula: C₁₁₁H₂₀₆N₃₆O₂₈S₂

Molecular weight: Approximately 2512–2555 Da

Form: Lyophilized powder, purity usually ≥99% (HPLC)

II. Mechanism of Action (Core Principle)

Precise targeting: The N‑terminal sequence specifically binds to the Prohibitin protein on the endothelium of white adipose blood vessels, acting only on the adipose blood supply system.

Blood supply disruption: The C‑terminal pro‑apoptotic domain induces apoptosis of vascular endothelial cells, blocking oxygen and nutrient supply to adipocytes.

Adipose elimination: Adipocytes die from ischemia and hypoxia and are metabolically cleared by the body, achieving localized fat reduction.

Metabolic improvement: Along with the reduction of visceral fat, insulin sensitivity is enhanced, and blood glucose and lipid profiles are optimized.

III. Preclinical Research Results (Animal Experiments)

Obese mice: Body weight decreased by approximately 30% within 4 weeks, with a significant reduction in visceral fat, without affecting food intake or muscle mass.

Rhesus monkeys: Obvious decreases in body weight and fat mass occurred within several weeks, with preferential reduction of visceral fat.

Metabolic benefits: Improved insulin resistance, reduced fasting blood glucose and triglycerides, and effective in models of metabolic syndrome.

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