BENZYL ALCOHOL
Product Description
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Basic InformationMolecular Formula: ()Molecular Weight: 108.14CAS No.: 100-51-6Synonyms: Benzyl alcohol, α-hydroxytoluene, phenylmethanol
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Physical PropertiesAppearance: Colorless transparent liquid with a faint aromatic odorMelting Point: -15.3℃Boiling Point: 205.3℃Density: 1.045 g/mL (25℃)Solubility: Slightly soluble in water (4.29 g/100 mL, 20℃), miscible with organic solvents such as ethanol, ether, acetone and benzeneFlash Point: 100℃ (closed cup)Vapor Pressure: 0.13 kPa (58℃)
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Chemical PropertiesOxidation Reaction: Easily oxidized to benzaldehyde and further to benzoic acidEsterification Reaction: Reacts with organic acids to form benzyl esters, which are important intermediates for fragrances and plasticizersHalogenation Reaction: Reacts with hydrohalic acids and phosphorus halides to form benzyl halides (common alkylating agents)Stability: Stable at room temperature; prone to oxidation upon prolonged storage to produce benzaldehyde (with a bitter almond odor)
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Main Applications
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Pharmaceutical FieldInjection Solvent/Analgesic: Reduces injection pain, e.g., as a solvent for spectinomycinLocal Anesthesia/Antisepsis: Preservative for topical preparations, eye drops and injectionsHead Lice Treatment: For head lice infestations in patients aged 6 months and above
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Daily Chemicals and FragrancesPerfumes and Cosmetics: Solvent, fixative and preservativeFlavor Raw Material: Used in floral fragrances such as jasmine and hyacinth
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Food IndustryFood Additive (E1519): Preservative and flavor enhancerApplications: Candies, baked goods, beverages, chewing gum, etc.
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Industrial ApplicationsSolvent: Coatings, inks, epoxy resins, adhesives, cleaning agentsOrganic Synthesis: Preparation of benzyl esters, benzyl ethers, dyes and pharmaceutical intermediatesPlasticizer: Used in the processing of cellulose esters and resins
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SafetyToxicity: Low toxicity (Cramer Class I), with certain toxicity upon oral or dermal absorptionIrritation: Irritating to skin, eyes and mucous membranes, may cause contact dermatitisContraindication: Prohibited for intramuscular injection in neonates (may cause gasping syndrome)Storage: Cool, well-ventilated, sealed, away from fire sources and oxidizing agents
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Natural SourcesNaturally occurs in essential oils such as jasmine, hyacinth and ylang-ylang, as well as in fruits and tea leaves, mostly in the form of esters.
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Industrial PreparationChlorination-Hydrolysis Method (Mainstream): Toluene is chlorinated to form benzyl chloride, which is then hydrolyzed to obtain benzyl alcoholCannizzaro Reaction: Benzaldehyde undergoes disproportionation in alkali to produce benzyl alcohol and benzoic acid
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