HGH 191AA -Yuan peptide

HGH 191AA

Product Description

HGH 191AA (Somatropin, Recombinant Human Growth Hormone) is a single-chain polypeptide consisting of 191 amino acids with an identical amino acid sequence to the naturally secreted human growth hormone. It is currently the most mainstream growth hormone preparation in clinical and scientific research, with a structure closest to the physiological one.

I. Basic Information

Full Name: Human Growth Hormone 191 Amino Acids

Aliases: Somatropin, rhGH, hGH-N

Structure: Single-chain non-glycosylated polypeptide containing 191 amino acids, with a molecular weight of approximately 22 kDa and 2 intramolecular disulfide bonds

Source: Expressed and produced in Escherichia coli (E. coli) via genetic recombination technology

Nature: Identical in structure and function to the natural growth hormone secreted by the anterior pituitary gland in humans

II. Core Mechanism of Action

HGH 191AA exerts its effects through two pathways: direct action and indirect action (mediated by IGF-1):

Direct Action

Binds to growth hormone receptors (GHR) on the surface of target cells throughout the body

Activates signaling pathways such as JAK-STAT

Directly regulates: protein synthesis, lipolysis, glucose metabolism, cell proliferation and repair

Indirect Action (Primary Pathway)

Stimulates the liver and peripheral tissues to secrete large amounts of insulin-like growth factor-1 (IGF-1)

As a "second messenger", IGF-1 mediates most growth-promoting, anabolic, and tissue-repairing effects

III. Major Physiological Functions

Growth and Development Promotion (Children/Adolescents)

Stimulates the proliferation of epiphyseal chondrocytes in long bones, promoting height increase

Promotes the development and volume enlargement of muscles and visceral organs

Metabolic Regulation (All Age Groups)

Anabolism: Promotes protein synthesis, reduces muscle breakdown, and maintains positive nitrogen balance

Fat Metabolism: Activates lipase, accelerates lipolysis (fat reduction), and lowers body fat percentage

Glucose Metabolism: Inhibits glucose uptake by peripheral tissues, slightly elevating blood glucose (tendency toward insulin resistance)

Tissue Repair and Anti-Aging

Promotes the regeneration and repair of cells in tissues such as the skin, bones, tendons, and viscera

Improves skin elasticity, reduces wrinkles, and enhances sleep quality

Others

Enhances immune function, increases bone mineral density, and improves physical performance and energy

IV. Clinical Applications (Legitimate Medical Scenarios)

Growth hormone deficiency in children: Treatment of short stature

Growth disorders caused by Turner syndrome, Prader-Willi syndrome, chronic renal insufficiency, etc.

Adult growth hormone deficiency: Improves body composition, bone mineral density, and quality of life

Adjuvant treatment for short bowel syndrome, burns, post-traumatic repair, etc.

V. Potential Risks and Side Effects (Extremely High Risk of Non-Medical Abuse)

Metabolism-Related: Elevated blood glucose, insulin resistance, edema, joint pain

Skeletal/Soft Tissue: Abuse in adults may cause acromegaly (enlarged hands and feet, facial changes, visceral hypertrophy)

Others: Hypothyroidism, headache, nausea, potential tumor risk (especially in individuals with a prior medical history)

Legal and Safety: Non-medical use is illegal in most countries worldwide; black-market products have no guaranteed purity or dosage, posing significant risks

VI. Differences from Other Growth Hormone Preparations

HGH 191AA (Somatropin): 191 amino acids, fully consistent with natural hGH, with the highest biological activity and relatively controllable side effects

HGH 20kD: 176 amino acids (deletion of positions 32–46), low activity, rarely used clinically

HGH 176–191: C-terminal fragment, only retains potent fat-reducing effects with no obvious growth-promoting effects

VII. Important Notes

Medical Use: Must be used under strict evaluation and monitoring by an endocrinologist, with regular checks of IGF-1, blood glucose, thyroid function, etc.

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