ARA-290
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ARA-290

ARA-290

Product Description

ARA-290 (Generic Name: cibinetide) is a synthetic linear peptide consisting of 11 amino acids, modified from the B helix structure of EPO (Erythropoietin). Its core feature is that it retains the tissue-protective, anti-inflammatory and neurorestorative activities of EPO while having absolutely no erythropoietic side effects.

I. Basic Information

Alternative Names: Cibinetide, PHBSP, Helix B Surface Peptide
Sequence: QEQLERALNSS (The N-terminal glutamine can spontaneously cyclize to form pyroglutamic acid)
Molecular Weight: 1257 Da
Developer: Araim Pharmaceuticals
Core Patent: Selectively activates IRR (Innate Repair Receptor) without activating the hematopoietic EPOR homodimer

II. Mechanism of Action (Key: Hematopoiesis-devoid EPO mimetic peptide)

1. Receptor Selectivity (Core Feature)

EPO binds to two types of receptors simultaneously:
EPOR homodimer → Erythropoiesis (elevated blood viscosity, thrombotic risk)
EPOR/CD131 (βcR) heterodimer (IRR) → Tissue protection, anti-inflammation, anti-apoptosis and repair
ARA-290 only binds to and activates IRR, does not trigger the hematopoietic pathway at all, and poses no risks of polycythemia, hypertension or thrombosis.

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ARA-290

ARA-290

ARA-290 (Generic Name: cibinetide) is a synthetic linear peptide consisting of 11 amino acids, modified from the B helix structure of EPO (Erythropoietin). Its core feature is that it retains the tissue-protective, anti-i ...

VIEW MORE