Acetic Acid Water -Yuan peptide

Acetic Acid Water

Product Description

Acetic Acid Water (aqueous acetic acid/acetic acid water). In the field of peptide research, the most commonly used formulation is 0.6% sterile aqueous acetic acid solution (pH ≈ 3.0), a reagent specifically designed for the reconstitution of poorly soluble peptides. A professional and structured introduction is provided below from multiple dimensions:

I. Basic Information and Chemical Properties

Composition and Specification: Typically 0.6% (w/v) acetic acid dissolved in sterile water for injection; molecular formula CH₃COOH + H₂O. Acetic acid is a weak organic acid with a pKa of 4.76 (25°C), partially ionizing in water to render the solution acidic (pH ≈ 3.0).

Appearance: Colorless transparent liquid with a mild acetic acid odor.

Stability: Stable when stored sealed, cool and away from light; refrigerate after opening; do not subject to repeated high-temperature sterilization.

Note: "Asetic" is a spelling error of "Acetic". Distinguished from bacteriostatic water containing 0.9% benzyl alcohol (BAC Water, neutral pH ≈ 7.0).

II. Mechanism of Action (Core for Peptide Reconstitution)

Hydrophobic peptides with high isoelectric points (pI) tend to aggregate or gel in neutral water. 0.6% acetic acid water functions by:

Lowering the solution pH to well below the peptide's pI;

Protonating peptide molecules to carry a net positive charge;

The charge repulsion effect disrupts aggregation, enabling uniform dissolution, preventing gelation, and enhancing solution stability.

III. Application Scenarios and Usage

Applicable Peptides: High-pI peptides prone to aggregation such as AOD-9604, Frag 176-191; not suitable for GLP-1 lipidated peptides. Bacteriostatic water is preferred for conventional peptides.

Usage Method: First fully dissolve peptide powder in a small amount of acetic acid water until clear; then dilute to the target concentration with bacteriostatic water (balancing solubility and bacteriostasis).

Field: For laboratory research and peptide reagent preparation only; not for direct injection or consumption.

Common Packaging: 3ml and 10ml sterile vial packaging.

四、储存与安全

储存：未开封阴凉干燥处；开封后 2-8℃冷藏，尽快用完，避免污染；
安全：避免接触眼睛、皮肤黏膜；若接触用大量清水冲洗；酸性溶液不可与强碱混放；严格区分科研试剂与药用注射剂；
合规：仅用于研究，严禁临床或人体注射用途。

五、与抑菌水（BAC Water）对比

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